All cells in the body arise from a single fertilized egg. From this single origin, various specialized cells with widely differing tasks evolve through a process called cellular differentiation.

As cell therapy advances toward clinical reality, iPSC-derived cellular products, in vivo reprogramming strategies, and ...

Understanding how cells transform into specialized types during human development is a central challenge in biology. This complex process, known as cell differentiation, holds the key to understanding ...

Programmable recombinases let one cell produce multiple fates in preset ratios, enabling controlled division of labor, ...

Zimislecel is an allogeneic stem cell–derived islet-cell therapy. Data on the safety and efficacy of zimislecel in persons with type 1 diabetes are needed. We conducted a phase 1–2 study of zimislecel ...

How do stem cells know what to become? Nearly three decades after scientists isolated the first human embryonic stem cells, researchers are still working hard to understand precisely how a single, ...

Silicon nanotube arrays deliver functional mRNA into human pluripotent stem cells for the first time, achieving up to 64% transfection without compromising stem cell identity.