Competition between Quaking and SF1 for a subset of ACUAA intron branch sites influences alternative splicing in different tissues and organisms.

RNA splicing is a cellular process that is critical for gene expression. After genes are copied from DNA into messenger RNA, portions of the RNA that don't code for proteins, called introns, are cut ...

In amyotrophic lateral sclerosis and frontotemporal dementia, loss of nuclear TDP-43 mucks up splicing of many transcripts, squelching expression of the associated proteins. However, this missplicing ...