Structural environments of the methionine residues M252 (green) and M428 (blue) in the Fc region are shown. Upon oxidation, these residues are converted to methionine sulfoxide, generating two ...
Oxidation of saturated C−H bonds is a key chemical reaction in synthetic chemistry and chemical industry. Nevertheless, the high bond dissociation energies (BDEs) and weak polarity of C(sp 3)−H bonds, ...
Oxidation is a major degradation pathway for active pharmaceutical ingredients (APIs), particularly in solid dosage forms. It ...
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