A new LMU study shows how proteins function reliably even without a stable 3D structure – and the crucial importance not only of short sequence motifs, but also of the chemical characteristics.

Intrinsically disordered proteins lack a fixed structure, which is why they have been considered "undruggable" targets for ...

Every function in a cell is associated with a particular protein or group of proteins, typically in a well-defined three-dimensional structure. However, intrinsically disordered regions of proteins ...

A new LMU study shows how proteins function reliably even without a stable 3D structure—and the crucial importance not only of short sequence motifs, but also of chemical characteristics.

Intrinsically disordered proteins (IDPs) make up about 30 percent of our proteome. They are important to many fundamental aspects of biology and disrupted in disease. Since they lack a stable shape, ...

Researchers combined AI simulations with NMR data to capture fleeting structures of intrinsically disordered proteins, ...

An illustration of one of Grove Biopharma’s protein-like polymers in sky blue and bright yellow. These protein-like polymers may help target intractable cancer-causing proteins. Credit: Saeed Najafi, ...

In synthetic and structural biology, advances in artificial intelligence have led to an explosion of designing new proteins with specific functions, from antibodies to blood clotting agents, by using ...

RIKEN researchers have discovered how an enzyme modifies gene expression by targeting certain stretches of messenger RNA ...

Different DNA Structures Nucleate the Folding of Proteins to form specific complexes that modulate the readout of genetic information Self-organization is inherent in the way Nature has engineered ...

Researchers at Harvard and Northwestern have developed a machine learning method that can design intrinsically disordered proteins with custom properties, addressing nearly 30% of all human proteins ...