Adrenomedullin disrupts insulin signaling in blood vessels, leading to systemic insulin resistance in obesity-associated type 2 diabetes, according to a new study by a team at the Max Planck Institute ...

Insulin is one of the most potent and pleiotropic hormones in the body, regulating a myriad of physiological processes. However, perhaps none is best studied as its role in regulating glucose ...

Insulin resistance plays a role in many diseases. The new research provides insights into why insulin resistance appears to be associated with neurodegenerative disorders. Corresponding author Kai ...

Developing resistance to insulin is a key step on the road to diabetes, making insulin resistance a target for treating metabolic dysfunction. Insulin orchestrates blood glucose levels by signaling ...

Scientists have revealed how a population of insulin-producing cells (IPCs) in the fruit fly brain works together to produce a concerted response to metabolic demands and internal state changes.

Researchers at the University of São Paulo (USP) in Brazil have succeeded in showing, in an animal model, that the process of insulin resistance in the brain affects both Alzheimer’s disease and ...

Obesity causes insulin resistance by increasing activation of the sympathetic nervous system and the release of the stress hormone norepinephrine, according to a new study. A study from Rutgers Health ...

Obesity has become a global epidemic affecting diverse populations and leading to metabolic syndrome across different sexes and age groups. A significant aspect of obesity is the development of leptin ...

Obesity is known to be a major risk factor that exacerbates metabolic disorders, such as type 2 diabetes. A key molecule ...

Metabolic dysfunction may be more than a comorbidity in bipolar disorder—it could be a key driver of disease progression and ...

When lipid biologist Usha Acharya at the National Cancer Institute (NCI) tinkered with lipid breakdown pathways in Drosophila melanogaster, she observed something intriguing. Blocking a biochemical ...