UC Davis researchers have confirmed a central idea about chromosome repair, more than a quarter century after it was first proposed. The finding is important to scientists who seek to understand DNA ...

Replication forks formed at bacterial origins often encounter template roadblocks in the form of DNA adducts and frozen protein-DNA complexes, leading to replication-fork stalling and inactivation.

Homologous recombination is one mechanism for repairing double-stranded DNA breaks. It involves the exchange of nucleotide sequences to repair damaged bases on both strands of DNA through the ...

Crossing over is believed to involve an intermediate in which homologues are linked by two crossed-strand structures called Holliday junctions. This model, based on observations in Saccharomyces ...

The orange wheel shows the circular chromosome or genome of E. coli bacteria. The spikes indicate where a molecular intermediate in DNA repair -- four-way DNA junctions -- accumulate near a reparable ...

The repair of double-stranded DNA breaks (DSBs) is essential for genomic integrity and cell survival. In addition to a central role in meiosis, homologous recombination is also the main DSB repair ...