A vanadium MXene nanoparticle uses gene editing to strip tumors of heat resistance, then kills them with laser-triggered free ...

Imagine the life of a yeast cell, floating around the kitchen in a spore that eventually lands on a bowl of grapes. Life is good: food for days, at least until someone notices the rotting fruit and ...

The heat shock response of cells is a classic model of biological adaptation, part of the fundamental processes of life -- conserved in creatures from single-celled yeast to humans -- that allow our ...

The combination of mild electrical stimulation and heat shock at 42 °C (MES+HS) exerts anti-inflammatory and anti-fibrotic effects in a mouse model of nephrotic syndrome (NS) by inhibiting apoptosis ...

The first full-length structures of two heat shock chaperone proteins in a complex reveal the key structural region regulating their function, according to a new study from St. Jude Children's ...

Rising temperatures disrupt human cellular stability by impairing proteostasis, altering mitochondrial function, reprogramming gene expression, and reshaping immune responses, ultimately shifting ...

STAT3 as a molecular target in pediatric T-cell leukemia. Background: HSP90 plays a central role in regulating client proteins involved in malignant processes. Currently, geldanamycin derivatives have ...

Differential outcomes in patients treated with endocrine therapy for early or locally advanced breast cancer based on BRCA mutation status No significant financial relationships to disclose. This is ...

Hyperthermia, a cancer treatment using controlled heat to kill tumor cells, shows promise but faces limitations due to some tumor cells' unexpected heat resistance. Researchers from Japan have now ...

A research team from Kumamoto University in Japan has found that the combination of weak pulsed electrical current and heat exerts anti-inflammatory and anti-fibrotic effects in the kidneys, as well ...