Differentiation of periperal T cells into T H 1 and T H 2 subsets is a crucial part of a normal immune response. Evidence is emerging that a signaling pathway involving the SAP molecule may play an ...
Mutations that affect the adaptor molecule SLAM-associated protein (SAP) lead to the genetic disorder X-linked lymphoproliferative syndrome (XLP), which is characterized by severe, often fulminant ...
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