The RASopathies, which include Noonan syndrome (NS) and Cardiofaciocutaneous syndrome (CFC), are autosomal dominant disorders with genetic heterogeneity associated with germline mutations of genes in ...

Mutations in components of the RAS-MAPK pathway provide a unifying mechanism for several phenotypically overlapping, yet clinically distinct human 'neuro-cardio-facial-cutaneous' (NCFC) syndromes.

Noonan syndrome is a hereditary condition that occurs when a person inherits a certain genetic mutation from a parent. A genetic mutation may also occur at conception due to an irregularity in the egg ...