Cell- and animal-based models of bone formation reveal novel mechanisms involved in the cartilage-to-bone phenotype ...

Typically, bone marrow research relies heavily on animal models and oversimplified cell cultures in the laboratory. Now, researchers from the Department of Biomedicine at the University of Basel and ...

Bone health relies on a balance between osteoblasts (builders) and osteoclasts (recyclers). Peak bone mass occurs in early adulthood; deficiencies during this window amplify fracture risks later in ...

Researchers recently developed a bone marrow model to study how the body generates cells. Interestingly, this model is the first of its kind to be developed entirely from human cells. Not only can ...

The first 'blueprint' of human skeletal development reveals how the skeleton forms, shedding light on the process of arthritis, and highlighting cells involved in conditions that affect skull and bone ...

The GPR133 receptor is expressed by osteoblasts, the cells that make bone. The study suggests that this receptor helps those cells sense two kinds of input: mechanical strain and signals relayed by ...

Bone implants often fail to fully integrate with surrounding tissue, limiting their effectiveness in regeneration. A natural but often overlooked cellular process could hold the key to better outcomes ...

What do healthy bone marrow cells in children look like? For the first time, researchers have mapped this out. Scientists at the Princess Máxima Center examined nearly 91,000 individual bone marrow ...

Musculoskeletal disorders are a primary cause of disability worldwide, especially in aging societies like Japan. As ...